Transcortical BOLD impulse response functions: Implications for layer-specific CMRO2 calculation
نویسندگان
چکیده
middle and lower cortical layers. The 30s stimulation period is marked with a red bar. The measured BOLD signal is the sum of the modeled response (the convolution of the input signal and the h, transfer function) and the residual signal (red line). The residue signals in every case are within the variability of the BOLD measurement, which indicates a good fit of the convolution model. Transcortical BOLD impulse response functions: Implications for layer-specific CMRO2 calculation
منابع مشابه
BOLD impulse response functions in the somatosensory cortex: Implications for CMRO2 calculation
P. Herman, B. G. Sanganahalli, H. Blumenfeld, and F. Hyder Diagnostic Radiology, Yale University, New Haven, CT, United States, Institute of Human Physiology and Clinical Experimental Research, Semmelweis University, Budapest, Hungary, Neurology, Yale University, New Haven, CT, United States, Neurobiology, Yale University, New Haven, CT, United States, Biomedical Engineering, Yale University, N...
متن کاملArterial impulse model for the BOLD response to brief neural activation
The blood oxygen level dependent (BOLD) signal evoked by brief neural stimulation, the hemodynamic response function (HRF), is a critical feature of neurovascular coupling. The HRF is directly related to local transient changes in oxygen supplied by cerebral blood flow (CBF) and oxygen demand, the cerebral metabolic rate of oxygen (CMRO2). Previous efforts to explain the HRF have relied upon th...
متن کاملChanges in Arterial Oxygen Tension with Evoked Stimulation in the Rat Somato-sensory Cortex: Implications for Quantitative fMRI
Introduction It is accepted that the BOLD fMRI signal results from changes in the amount and saturation of hemoglobin in a voxel that stem from neurophysiological changes in CBF, CBV and CMRO2 with brain activation. This sensitivity of BOLD fMRI to CMRO2 has been used to quantify the changes in CMRO2 with brain activation (1,2,3). In general, this physiological parameter has been of interest be...
متن کاملThe absolute CBF response to activation is preserved during elevated perfusion: Implications for neurovascular coupling measures
Functional magnetic resonance imaging (fMRI) techniques in which the blood oxygenation level dependent (BOLD) and cerebral blood flow (CBF) response to a neural stimulus are measured, can be used to estimate the fractional increase in the cerebral metabolic rate of oxygen consumption (CMRO2) that accompanies evoked neural activity. A measure of neurovascular coupling is obtained from the ratio ...
متن کاملVariability of the coupling of blood flow and oxygen metabolism responses in the brain: a problem for interpreting BOLD studies but potentially a new window on the underlying neural activity
Recent studies from our group and others using quantitative fMRI methods have found that variations of the coupling ratio of blood flow (CBF) and oxygen metabolism (CMRO2) responses to a stimulus have a strong effect on the BOLD response. Across a number of studies an empirical pattern is emerging in the way CBF and CMRO2 changes are coupled to neural activation: if the stimulus is modulated to...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008